Evaluation of Homologous Recombination Deficiency in Ovarian Cancer

Author:

Ratnaparkhi Rubina,Javellana Melissa,Jewell Andrea,Spoozak Lori

Publisher

Springer Science and Business Media LLC

Reference109 articles.

1. González-Martín A, Harter P, Leary A, Lorusso D, Miller RE, Pothuri B, et al. Newly diagnosed and relapsed epithelial ovarian cancer: ESMO clinical practice guideline for diagnosis, treatment, and follow-up. Ann Oncol. 2023;S0923–7534(23):00797–4. https://doi.org/10.1016/j.annonc.2023.07.011.

2. González-Martín A, Pothuri B, Vergote I, DePont Christensen R, Graybill W, Mirza MR, et al. Niraparib in patients with newly diagnosed advanced ovarian cancer. N Engl J Med. 2019;381(25):2391–402. https://doi.org/10.1056/NEJMoa1910962.

3. Moore K, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, et al. Maintenance olaparib in patients with newly diagnosed advanced ovarian cancer. N Engl J Med. 2018;379(26):2495–505. https://doi.org/10.1056/NEJMoa1810858.

4. • Miller RE, Leary A, Scott CL, Serra V, Lord CJ, Bowtell D, et al. ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer. Ann Oncol. 2020;31(12):1606–1622. https://doi.org/10.1016/j.annonc.2020.08.2102. This reference is of importance as it outlines the European Society for Medical Oncology’s finalized recommendations for homologous recombination deficiency testing based on expert committee review of recently published literature and their strength of evidence.

5. Heeke AL, Pishvaian MJ, Lynce F, Xiu J, Brody JR, Chen WJ, et al. Prevalence of homologous recombination-related gene mutations across multiple cancer types. JCO Precis Oncol. 2018;2:1–13.

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