Management of bone metastases in breast cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Oncology
Link
http://link.springer.com/content/pdf/10.1007/s11864-005-0023-0.pdf
Reference44 articles.
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3. Theriault RL, Lipton A, Hortobagyi GN, et al.:Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions:a randomized, placebo-controlled trial. Protocol 18 Aredia Breast Cancer Study Group. J Clin Oncol 1999, 17:846–854.
4. Lipton A, Theriault RL, Hortobagyi GN, et al.:Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases:long term follow-up of two randomized, placebo-controlled trials. Cancer 2000, 88:1082–1090. This trial established the long-term safety and efficacy of pamidronate in patients with osteolytic lesions from breast cancer.
5. Major PP, Cook R:Efficacy of bisphosphonates in the management of skeletal complications of bone metastases and selection of clinical endpoints. Am J Clin Oncol 2002, 25(Suppl 1):10–18. This review article summarizes the challenges of assessing skeletal morbidity in patients with malignant bone disease and the respective merit of clinical trial endpoints in this setting. The results of clinical trials of bisphosphonates in patients with breast or prostate cancer are critically analyzed.
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