New Developments in Treating RAS-Mutated Metastatic Colorectal Cancer

Author:

Janssens KatleenORCID,Lambrechts Chinouk,Geerinckx BarbaraORCID,Op de Beeck KenORCID,Van Camp GuyORCID,Oliveres HelenaORCID,Prenen HansORCID,Vandamme TimonORCID,Peeters MarcORCID

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Oncology

Reference91 articles.

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2. Douillard JY, Oliner KS, Siena S, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, Rivera F, Kocakova I, Ruff P, Blasinska-Morawiec M, Smakal M, Canon JL, Rother M, Williams R, Rong A, Wiezorek J, Sidhu R, Patterson SD. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 2013;369(11):1023–34. https://doi.org/10.1056/NEJMoa1305275.

3. Van Cutsem E, Lenz HJ, Kohne CH, Heinemann V, Tejpar S, Melezinek I, Beier F, Stroh C, Rougier P, van Krieken JH, Ciardiello F. Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer. J Clin Oncol. 2015;33(7):692–700. https://doi.org/10.1200/JCO.2014.59.4812.

4. Stahler A, Heinemann V, Ricard I, von Einem JC, Giessen-Jung C, Westphalen CB, Michl M, Heinrich K, Miller-Phillips L, Jelas I, Stintzing S, Modest DP. Current treatment options in RAS mutant metastatic colorectal cancer patients: a meta-analysis of 14 randomized phase III trials. J Cancer Res Clin Oncol. 2020;146(8):2077–87. https://doi.org/10.1007/s00432-020-03290-y.

5. Gimple RC, Wang X. RAS: striking at the core of the oncogenic circuitry. Front Oncol. 2019;9:965. https://doi.org/10.3389/fonc.2019.00965.

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