Implications of ESR1 Mutations in Hormone Receptor-Positive Breast Cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Oncology
Link
http://link.springer.com/article/10.1007/s11864-018-0542-0/fulltext.html
Reference66 articles.
1. Josefsson M, Leinster S. Aromatase inhibitors versus tamoxifen as adjuvant hormonal therapy for estrogen sensitive early breast cancer in post-menopausal women: meta-analyses of monotherapy, sequenced therapy and extended therapy. Breast. 2010;19:76–83.
2. •• Ma C, Reinert T, Chmielewska I, Ellis M. Mechanisms of aromatase inhibitors resistance. Nat Rev Cancer. 2015;15:261–75. Comprehensive review of mechanisms of resistance to AIs cancer considering both genomic and cell biological explanatations as to why ER+ breast cancer cells progress and cause an incurable systemic disease.
3. Huang B, Warner M, Gustafsson J. Estrogen receptors in breast carcinogenesis and endocrine therapy. Mol Cell Endocrin. 2014.
4. Reinert T, Saad ED, Barrios CH, Bines J. Clinical implications of ESR1 mutations in hormone receptor-positive advanced breast Cancer. Front Oncol. 2017;7:26.
5. •• Jeselsohn R, Buchwalter G, De Angelis C, et al. ESR1 mutations: a mechanism for acquired endocrine resistance in breast cancer. Nat Rev Clin Oncol. 2015;12:573–83. Very important publication that established the role of ESR1 as a mechanism of resistance present in AI-refractory patients but not as a mechanism of primary endocrine resistance.
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1. ESR1 Gene Mutations and Liquid Biopsy in ER-Positive Breast Cancers: A Small Step Forward, a Giant Leap for Personalization of Endocrine Therapy?;Cancers;2023-10-27
2. Accelerating drug development in breast cancer: New frontiers for ER inhibition;Cancer Treatment Reviews;2022-09
3. Novel Breast Cancer Treatment by Targeting Estrogen Receptor-Alpha Stability Using Proteolysis-Targeting Chimeras (PROTACs) Technology;Breast Cancer;2022-08-04
4. Decoding the Therapeutic Implications of the ERα Stability and Subcellular Distribution in Breast Cancer;Frontiers in Endocrinology;2022-04-13
5. Estrogen Receptor Bio-Activities Determine Clinical Endocrine Treatment Options in Estrogen Receptor-Positive Breast Cancer;Technology in Cancer Research & Treatment;2022-01
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