Active surveillance versus radical treatment for favorable-risk localized prostate cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Oncology
Link
http://link.springer.com/content/pdf/10.1007/s11864-006-0003-z.pdf
Reference32 articles.
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4. Welch HG, Schwartz LM, Woloshin S: Prostate-specific antigen levels in the United States: implications of various definitions for abnormal. J Natl Cancer Inst 2005, 97:1132–1137.
5. Thompson IM, Goodman PJ, Tangen CM, et al.: The influence of finasteride on the development of prostate cancer. N Engl J Med 2003, 349:215–224 This landmark trial was the first to subject a large cohort of men with a normal PSA to prostate biopsy; it showed a 25% positive biopsy rate in the placebo arm, confirming the serious risks of overdiagnosis of clinically insignificant disease. It also showed a 25% reduction in the risk of diagnosing prostate cancer in men treated with finasteride for 7 years.
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