Locally advanced and metastatic bladder cancer

Author:

Dreicer Robert

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Oncology

Reference28 articles.

1. Saxman SB, Propert KJ, Einhorn LH, et al.: Long-term follow-up of a phase III intergroup study of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study. J Clin Oncol 1997, 15:2564–2569. This is an update of the prospective, randomized intergroup trial that established the superiority of MVAC compared with cisplatin, and documented a 3.7% survival of MVAC-treated patients at a median follow-up of 6 years.

2. Roth BJ, Dreicer R, Einhorn LH, et al.: Significant activity of paclitaxel in advanced transitional cell carcinoma of the urothelium: a phase II trial of the Eastern Cooperative Oncology Group. J Clin Oncol 1994, 12:2264–2270.

3. Stadler WM, Kuzel T, Roth B, et al.: Phase II study of single-agent gemcitabine in previously untreated patients with metastatic urothelial cancer. J Clin Oncol 1997, 15:3394–3398.

4. Vaughn DJ, Malkowicz SB: Recent advances in bladder cancer chemotherapy. Cancer Invest 2001, 19:77–85.

5. Loehrer PJ, Einhorn LH, Elson PJ, et al.: A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study. J Clin Oncol 1992, 10:1066–1073. The original report of the Intergroup randomized trial establishing MVAC as superior to single-agent cisplatin in advanced urothelial cancer. The investigators noted the role of various prognostic factors in predicting response.

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