Gastrointestinal stromal tumors: Imatinib and beyond
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Oncology
Link
http://link.springer.com/content/pdf/10.1007/s11864-006-0018-5.pdf
Reference48 articles.
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2. Nilsson B, Bumming P, Meis-Kindblom JM, et al.:Gastrointestinal stromal tumors:the incidence, prevalence, clinical course, and prognostication in the pre-imatinib mesylate—a population-based study in western Sweden. Cancer 2005, 103:821–829. This study provides the best available epidemiologic data for GISTs, from which US incidence and prevalence are extrapolated.
3. DeMatteo RP, Lewis JJ, Leung D, et al.:Two hundred gastrointestinal stromal tumors:recurrence patterns and prognostic factors for survival. Ann Surg 2000, 231:51–58. This paper presents excellent retrospective data from 200 surgical GIST patients. It provides useful information on surgical outcomes and the natural history of the disease across a diverse GIST patient population.
4. Rubin BP, Singer S, Tsao C, et al.:KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 2001, 61:8118–8121.
5. Heinrich MC, Corless CL, Duensing A, et al.:PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003, 299:708–710. This important translational research demonstrated that PDGFRA mutations have the same downstream targets as KIT mutations; it establishes this receptor's importance in GIST pathogenesis.
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