Characterisation of urinary metabolites of temozolomide in humans and mice and evaluation of their cytotoxicity

Author:

Tsang Lincoln L. H.,Farmer Peter B.,Gescher Andreas,Slack John A.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference21 articles.

1. Angelo HR, Herrstedt J, Jorgensen M (1989) High-performance liquid chromatographic method with fluorescence detection for the simultaneous determination of metopimazine and its acid metabolite in serum. J Chromatogr 496: 427

2. Baig GU, Stevens MFG (1987) Antitumour imidazotetrazines: XII. Reaction of mitozolomide and its 3-alkyl congeners with oxygen, nitrogen, halogen and carbon nucleophiles. J Chem Soc Perkin Trans 1: 665

3. Bill CA, Gescher A, Hickman JA (1988) Effects ofN-methylformamide on the growth, cell cycle, and glutathione status of murine TLX5 lymphoma cells. Cancer Res 48: 3389

4. Clark AS, Stevens MFG, Sansom CE, Schwalbe CH (1990) Antitumour imidazotetrazines: XXI. Mitozolomide and temozolomide: probes for the major groove of DNA. Anticancer Drug Design 5: 63

5. Engineer MS, Raber MN, Newman RA (1988) Clinical Pharmacology of LY195 448. Proc Am Assoc Cancer Res 29: 195

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