New insights into the mechanisms of anandamide-induced airway dilation placing its degradation enzyme, FAAH center stage. Commentary on: Simon A, von Einem T, Seidinger A, Matthey M, Bindila L, Wenzel D (2022) The endocannabinoid anandamide is an airway relaxant in health and disease. Nat Commun 13:6941
Author:
Funder
Universitätsklinikum Köln
Publisher
Springer Science and Business Media LLC
Subject
Physiology (medical),Clinical Biochemistry,Physiology
Link
https://link.springer.com/content/pdf/10.1007/s00424-023-02802-2.pdf
Reference12 articles.
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2. Clarke DL, Dakshinamurti S, Larsson AK, Ward JE, Yamasaki A (2009) Lipid metabolites as regulators of airway smooth muscle function. Pulm Pharmacol Ther 22:426–435. https://doi.org/10.1016/j.pupt.2008.12.003
3. Dudášová A, Keir SD, Parsons ME, Molleman A, Page CP (2013) The effects of cannabidiol on the antigen-induced contraction of airways smooth muscle in the guinea-pig. Pulm Pharmacol Ther 26:373–379. https://doi.org/10.1016/j.pupt.2013.02.002
4. Genovese T, Duranti A, D’Amico R, Fusco R, Impellizzeri D, Peritore AF, Crupi R, Gugliandolo E, Cuzzocrea S, Di Paola R, Siracusa R, Cordaro M (2022) Fatty acid amide hydrolase (FAAH) inhibition plays a key role in counteracting acute lung injury. Int J Mol Sci 23:2781. https://doi.org/10.3390/ijms23052781
5. Schurman LD, Lu D, Kendall DA, Howlett AC, Lichtman AH (2020) Molecular mechanism and cannabinod pharmacology. Handb Exp Pharmacol 258:323–363. https://doi.org/10.1007/164_2019_298
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