ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel

Author:

Barro-Soria René,Aldehni Fadi,Almaça Joana,Witzgall Ralph,Schreiber Rainer,Kunzelmann Karl

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Clinical Biochemistry,Physiology

Reference47 articles.

1. AlDehni F, Spitzner M, Martins JR, Barro Soria R, Schreiber R, Kunzelmann K (2009) Role of bestrophin for proliferation and in epithelial to mesenchymal transition. J Am Soc Nephrol 20:1556–1564

2. Almaca J, Tian Y, AlDehni F, Ousingsawat J, Kongsuphol P, Rock JR, Harfe BD, Schreiber M, Kunzelmann K (2009) TMEM16 proteins produce volume regulated chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem. doi: 10.1074/jbc.M109.010074

3. Bachhuber T, König J, Voelcker T, Mürle B, Schreiber R, Kunzelmann K (2005) Chloride interference with the epithelial Na+ channel ENaC. J Biol Chem 280:31587–31594

4. Barro Soria R, Schreiber R, Kunzelmann K (2008) Bestrophin 1 and 2 are components of the Ca2+ activated Cl− conductance in mouse airways. Biochim Biophys Acta 1783:1993–2000

5. Barro Soria R, Spitzner M, Schreiber R, Kunzelmann K (2006) Bestrophin 1 enables Ca2+ activated Cl− conductance in epithelia. J Biol Chem 281:17460–17467

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