Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle-Reference-Cited by-同舟云学术

Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle

Published:2021-08-20 Issue:11 Volume:473 Page:1761-1773
ISSN:0031-6768
Container-title:Pflügers Archiv - European Journal of Physiology
language:en
Short-container-title:Pflugers Arch - Eur J Physiol

Author:

Park Jae Mo^ORCID,Josan Sonal,Hurd Ralph E.,Graham James,Havel Peter J.,Bendahan David,Mayer Dirk,Chung Youngran,Spielman Daniel M.,Jue Thomas^ORCID

Funder

National Institutes of Health

U.S. Department of Defense

Welch Foundation

France Berkeley Fund

California Department of Public Health

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Clinical Biochemistry,Physiology

Link

https://link.springer.com/content/pdf/10.1007/s00424-021-02613-3.pdf

Reference70 articles.

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2. Atherton HJ, Schroeder MA, Dodd MS, Heather LC, Carter EE, Cochlin LE, Nagel S, Sibson NR, Radda GK, Clarke K, Tyler DJ (2011) Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS. NMR Biomed 24:201–208. https://doi.org/10.1002/nbm.1573

3. Backshear PJ, Holloway PA, Alberti KG (1975) Metabolic interactions of dichloroacetate and insulin in experimental diabetic ketoacidosis. Biochem J 146:447–456. https://doi.org/10.1042/bj1460447

4. Bastiaansen JAM, Yoshihara HAL, Takado Y, Gruetter R, Comment A (2014) Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle. Metabolomics 10:986–994. https://doi.org/10.1007/s11306-014-0630-5

5. Befroy DE, Petersen KF, Dufour S, Mason GF, de Graaf RA, Rothman DL, Shulman GI (2007) Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes 56:1376–1381. https://doi.org/10.2337/db06-0783

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