Author:
Dowty James G.,Yu Chenglong,Hosseinpour Mahnaz,Joo Jihoon Eric,Wong Ee Ming,Nguyen-Dumont Tu,Rosenbluh Joseph,Giles Graham G.,Milne Roger L.,MacInnis Robert J.,Dugué Pierre-Antoine,Southey Melissa C.
Abstract
AbstractDNA methylation marks that are inherited from parents to offspring are known to play a role in cancer risk and could explain part of the familial risk for cancer. We therefore conducted a genome-wide search for heritable methylation marks associated with prostate cancer risk. Peripheral blood DNA methylation was measured for 133 of the 469 members of 25 multiple-case prostate cancer families, using the EPIC array. We used these families to systematically search the genome for methylation marks with Mendelian patterns of inheritance, then we tested the 1,000 most heritable marks for association with prostate cancer risk. After correcting for multiple testing, 41 heritable methylation marks were associated with prostate cancer risk. Separate analyses, based on 869 incident cases and 869 controls from a prospective cohort study, showed that 9 of these marks near the metastable epiallele VTRNA2-1 were also nominally associated with aggressive prostate cancer risk in the population.
Funder
Prostate Cancer Foundation of Australia
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics (clinical),Oncology,Genetics
Cited by
2 articles.
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