Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU)

Author:

Beumer Jan H.,Parise Robert A.,Newman Edward M.,Doroshow James H.,Synold Timothy W.,Lenz Heinz-Josef,Egorin Merrill J.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference19 articles.

1. Beumer JH, Eiseman JL, Parise RA, Joseph E, Holleran JL, Covey JM, Egorin MJ (2006) Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine in mice. Clin Cancer Res 12:7483–7491

2. Beumer JH, Parise RA, Newman EM, Doroshow JH, Synold TW, Lenz H, Egorin MJ (2006) Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) and its metabolites 5-fluoro-2′-deoxyuridine (FdUrd), 5-fluorouracil (FU), 5-fluorouridine (FUrd), and 5-fluorocytosine (FC) in plasma of patients treated with FdCyd. Proc Am Soc Clin Oncol 25:845

3. Boothman DA, Briggle TV, Greer S (1987) Tumor-selective metabolism of 5-fluoro-2′-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma. Cancer Res 47:2354–2362

4. Dareer SM, Mulligan LT Jr, White V, Tillery K, Mellett LB, Hill DL (1977) Distribution of [3H]cytosine arabinoside and its products in mice, dogs, and monkeys and effect of tetrahydrouridine. Cancer Treat Rep 61:395–407

5. BRENDA The comprehensive enzyme information system. http://wwwbrendauni-koelnde/indexphp4 (2005) http://www.brenda.uni-koeln.de/index.php4 . Accessed 28 Nov 2005

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