A phase 1b, multicenter, open-label, dose-finding study of eribulin in combination with carboplatin in advanced solid tumors and non-small cell lung cancer

Author:

Goel SanjayORCID,Swami Umang,Kumar Kirushna,Dittrich Christian,Reyderman Larisa,Jain Minish,Aisner Joseph,Song James,Petrylak Daniel P.

Funder

Eisai Inc.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference29 articles.

1. Dybdal-Hargreaves NF, Risinger AL, Mooberry SL (2015) Eribulin mesylate: mechanism of action of a unique microtubule-targeting agent. Clin Cancer Res 21:2445–2452

2. Smith JA, Wilson L, Azarenko O, Zhu X, Lewis BM, Littlefield BA, Jordan MA (2010) Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. Biochemistry 49:1331–1337

3. SEER Cancer Statistics Factsheets: Lung and Bronchus Cancer. Bethesda, MD: National Cancer Institute. http://seer.cancer.gov/statfacts/html/lungb.html. Accessed 18 Apr 2019

4. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines®) (2018) Non-small cell lung cancer. Version 2.2018. https://www.nccn.org/professionals/physician_gls/pdf/sclc.pdf. Accessed 18 Apr 2019

5. Synold TW, Morgan RJ, Newman EM, Lenz HJ, Gandara DR, Colevas AD, Lewis MD, Doroshow J (2005) A phase I pharmacokinetic and target validation study of novel anti-tubulin agent E7389: a California Cancer Consoritum [abstract]. J Clin Oncol 23(16 suppl):3036

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