Phase I/Ib study of crenolanib with ramucirumab and paclitaxel as second-line therapy for advanced esophagogastric adenocarcinoma

Author:

Moy Ryan H.ORCID,Greally Megan,Chou Joanne F.,Li Jia,Desai Avni M.,Chalasani Sree B.,Won Elizabeth,Kelsen David P.,Ilson David H.,Janjigian Yelena Y.,Capanu Marinela,Ku Geoffrey Y.ORCID

Funder

Arog Pharmaceuticals

National Cancer Institute

Damon Runyon Cancer Research Foundation

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference46 articles.

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3. Codipilly DC, Sawas T, Dhaliwal L et al (2021) Epidemiology and outcomes of young-onset esophageal adenocarcinoma: an analysis from a population-based database. Cancer Epidemiol Biomark Prev 30:142–149. https://doi.org/10.1158/1055-9965.EPI-20-0944

4. Enzinger PC, Burtness BA, Niedzwiecki D et al (2016) CALGB 80403 (alliance)/E1206: a randomized phase II study of three chemotherapy regimens plus cetuximab in metastatic esophageal and gastroesophageal junction cancers. J Clin Oncol 34:2736–2742. https://doi.org/10.1200/JCO.2015.65.5092

5. Bang Y-J, Van Cutsem E, Feyereislova A et al (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 376:687–697. https://doi.org/10.1016/S0140-6736(10)61121-X

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