Disruption of microfilaments by cytochalasin B decreases accumulation of cisplatin in human epidermal carcinoma and liver carcinoma cell lines

Author:

Liang Xing-Jie,Yin Jun-Jie,Taylor Barbara,Winkovitch Stephen M.,Garfield Susan H.,Shen Ding-Wu,Gottesman Michael M.,Aszalos Adorjan

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference26 articles.

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2. Chen ZS, Mutoh M, Sumizawa T, et al (1998) An active efflux system for heavy metals in cisplatin-resistant human KB carcinoma cells. Exp Cell Res 240:312–320

3. Shen DW, Pastan I, Gottesman MM (1998) Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins. Cancer Res 58:268–275

4. Shen DW, Goldenberg S, Pastan I, Gottesman MM (2000) Decreased accumulation of [14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake. J Cell Physiol 183:108–116

5. Johnson SW, Swiggard PA, Handel LM, et al (1994) Relationship between platinum-DNA adduct formation and removal and cisplatin cytotoxicity in cisplatin-sensitive and -resistant human ovarian cancer cells. Cancer Res 54:5911–5916

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