A polymorphism in ABCA2 is associated with neutropenia induced by capecitabine in Japanese patients with colorectal cancer

Author:

Shibata Yukitaka,Matsumoto Natsumi,Murase Remi,Kubota Yutaro,Ishida Hiroo,Shimada Ken,Fujita Ken-ichiORCID

Funder

JSPS Grant-in-Aid for Early-Career Scientists

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference29 articles.

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2. de Man FM, Veerman GDM, Oomen-de Hoop E, Deenen MJ, Meulendijks D, Mandigers C, Soesan M, Schellens JHM, van Meerten E, van Gelder T, Mathijssen RHJ (2019) Comparison of toxicity and effectiveness between fixed-dose and body surface area-based dose capecitabine. Ther Adv Med Oncol 11:1758835919838964. https://doi.org/10.1177/1758835919838964

3. Leicher LW, de Graaf JC, Coers W, Tascilar M, de Groot JW (2017) Tolerability of capecitabine monotherapy in metastatic colorectal cancer: a real-world study. Drugs R D 17:117–124. https://doi.org/10.1007/s40268-016-0154-8

4. Twelves C, Wong A, Nowacki MP, Abt M, Burris H 3rd, Carrato A, Cassidy J, Cervantes A, Fagerberg J, Georgoulias V, Husseini F, Jodrell D, Koralewski P, Kroning H, Maroun J, Marschner N, McKendrick J, Pawlicki M, Rosso R, Schuller J, Seitz JF, Stabuc B, Tujakowski J, Van Hazel G, Zaluski J, Scheithauer W (2005) Capecitabine as adjuvant treatment for stage III colon cancer. N Engl J Med 352:2696–2704. https://doi.org/10.1056/NEJMoa043116

5. Doi T, Boku N, Kato K, Komatsu Y, Yamaguchi K, Muro K, Hamamoto Y, Sato A, Koizumi W, Mizunuma N, Takiuchi H (2010) Phase I/II study of capecitabine plus oxaliplatin (XELOX) plus bevacizumab as first-line therapy in Japanese patients with metastatic colorectal cancer. Jpn J Clin Oncol. https://doi.org/10.1093/jjco/hyq069

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