A semimechanistic-physiologic population pharmacokinetic/pharmacodynamic model for neutropenia following pemetrexed therapy

Author:

Latz Jane E,Karlsson Mats O,Rusthoven James J,Ghosh Atalanta,Johnson Robert D

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference55 articles.

1. Adjei AA (2003) Pemetrexed (Alimta): a novel multitargeted antifolate agent. Expert Rev Anticancer Ther 3:145–156

2. Alati T, Shih C, Pohland RC, Lantz FJ, Grindey GB (1992) Evaluation of the mechanism(s) of inhibition of the toxicity, but not the antitumor activity of lomotrexol (DDATHF) by folic acid. Proc Am Assoc Cancer Res 33:407

3. Alimta Drug Approval Package, Medical Review. Food and Drug Administration Web site. Available at: http://www.fda.gov/cder/foi/nda/2004/21-462.pdf_Alimta_Medr_P6.pdf. Page 257. Accessed September 20, 2004

4. Allen RH, Stabler SP, Savage DG, Lindenbaum J (1993) Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J 7:1344–1353

5. Bajetta E, Celio L, Buzzoni R et al (2003) Phase II study of pemetrexed disodium (Alimta) administered with oral folic acid in patients with advanced gastric cancer. Ann Oncol 14:1543–1548

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