Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1α

Author:

Koukourakis Michael I.,Giatromanolaki Alexandra,Chong Wen,Simopoulos Costantinos,Polychronidis Alexandros,Sivridis Efthimios,Harris Adrian L.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference34 articles.

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3. Shen H, Chen ZJ, Zilfou JT, Hopper E, Murphy M, Tew KD (2001) Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. J Pharmacol Exp Ther 297:1067–1073

4. Grdina DJ, Murley JS, Kataoka Y, Calvin DP (2002) Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine’s free thiol in human microvascular endothelial and glioma cells. Semin Radiat Oncol 12 [Suppl 1]:103–111

5. Purdie JW, Inhaber ER (1983) Interaction of cultured mammalian cells with WR-2721 and its thiol, WR-1065: implications for mechanisms of radioprotection. Int J Radiat Biol 43:517–527

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