A PK-PD model linking biomarker dynamics to progression-free survival in patients treated with everolimus and sorafenib combination therapy, EVESOR phase I trial
Author:
Funder
Hospices Civils de Lyon
Ligue Contre le Cancer
Novartis
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology
Link
https://link.springer.com/content/pdf/10.1007/s00280-023-04520-z.pdf
Reference39 articles.
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4. Tanaka C, O’Reilly T, Kovarik JM, Shand N, Hazell K, Judson I et al (2016) Identifying optimal biologic doses of everolimus (RAD001) in patients with cancer based on the modeling of preclinical and clinical pharmacokinetic and pharmacodynamic data. J Clin Oncol 26:1596–1602
5. Chappell WH, Steelman LS, Long JM, Kempf RC, Abrams SL, Franklin RA et al (2011) Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget 2:135–164
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