Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration

Author:

Brown Alan P.,Carlson Tage C. G.,Loi Cho-Ming,Graziano Michael J.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference19 articles.

1. Allen LF, Sebolt-Leopold J, Meyer MB (2003) CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol 30(5 Suppl. 16):105–116

2. Brown AP, Courtney C, Carlson T, Graziano M (2005) Administration of a MEK inhibitor results in tissue mineralization in the rat due to dysregulation of phosphorus and calcium homeostasis. Toxicologist 84(S-1):108 (abstract 529)

3. Dent P, Grant S (2001) Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action. Clin Cancer Res 7:775–783

4. Gelmon KA, Eisenhauer EA, Harris AL, Ratain MJ, Workman P (1999) Anticancer agents targeting signaling molecules and cancer cell environment: challenges for drug development? J Natl Cancer Inst 91(15):1281–1287

5. Hoshino R, Chatani Y, Yamori T, et al (1999) Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase pathway in human tumors. Oncogene 18:813–822

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