A phase I trial of perillyl alcohol in patients with advanced solid tumors

Author:

Azzoli Christopher G.,Miller Vincent A.,Ng Kenneth K.,Krug Lee M.,Spriggs David R.,Tong William P.,Riedel Elyn R.,Kris Mark G.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference23 articles.

1. Ariazi EA, Satomi Y, Ellis MJ, Haag JD, Shi W, Sattler CA, Gould MN (1999) Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. Cancer Res 59:1917

2. Barthelman M, Chen W, Gensler HL, Huang C, Dong Z, Bowden GT (1998) Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation. Cancer Res 58:711

3. Boon PJ, van der Boon D, Mulder GJ (2000) Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat. Toxicol Appl Pharmacol 167:55

4. Crowell PL, Siar Ayoubi A, Burke YD (1996) Antitumorigenic effects of limonene and perillyl alcohol against pancreatic and breast cancer. Adv Exp Med Biol 401:131

5. Elegbede JA, Elson CE, Tanner MA, Qureshi A, Gould MN (1986) Regression of rat mammary tumors following dietary d-limonene. J Natl Cancer Inst 76:323

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