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A novel TRAIL mutant-TRAIL-Mu3 enhances the antitumor effects by the increased affinity and the up-expression of DR5 in pancreatic cancer

  • Published:2018-08-24 Issue:5 Volume:82 Page:829-838
  • ISSN:0344-5704
  • Container-title:Cancer Chemotherapy and Pharmacology
  • language:en
  • Short-container-title:Cancer Chemother Pharmacol

Author:

Huang Min,Zhu Hong,Yi Cheng,Yan Juan,Wei Lijia,Yang Xi,Chen Shouchun,Huang Ying

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference38 articles.

1. Han Y, Park S, Kinyua AW, Andera L, Kim KW, Kim I (2014) Emetine enhances the tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of pancreatic cancer cells by downregulation of myeloid cell leukemia sequence-1 protein. Oncol Rep 31(1):456–462. https://doi.org/10.3892/or.2013.2838

2. Recio-Boiles A, Ilmer M, Rhea PR, Kettlun C, Heinemann ML, Ruetering J, Vykoukal J, Alt E (2016) JNK pathway inhibition selectively primes pancreatic cancer stem cells to TRAIL-induced apoptosis without affecting the physiology of normal tissue resident stem cells. Oncotarget 7(9):9890–9906. https://doi.org/10.18632/oncotarget.7066

3. Flores JP, Diasio RB, Saif MW (2017) Drug metabolism and pancreatic cancer. Ann Gastroenterol 30(1):54–61. https://doi.org/10.20524/aog.2016.0074

4. Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR, Gallinger S, Au HJ, Murawa P, Walde D, Wolff RA, Campos D, Lim R, Ding K, Clark G, Voskoglou-Nomikos T, Ptasynski M, Parulekar W, National Cancer Institute of Canada Clinical Trials G (2007) Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25 (15):1960–1966. https://doi.org/10.1200/JCO.2006.07.9525

5. Van Cutsem E, Vervenne WL, Bennouna J, Humblet Y, Gill S, Van Laethem JL, Verslype C, Scheithauer W, Shang A, Cosaert J, Moore MJ (2009) Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol 27(13):2231–2237. https://doi.org/10.1200/JCO.2008.20.0238

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