First-in-human multicenter phase I study of BMS-936561 (MDX-1203), an antibody-drug conjugate targeting CD70-Reference-Cited by-同舟云学术

First-in-human multicenter phase I study of BMS-936561 (MDX-1203), an antibody-drug conjugate targeting CD70

Published:2015-11-14 Issue:1 Volume:77 Page:155-162
ISSN:0344-5704
Container-title:Cancer Chemotherapy and Pharmacology
language:en
Short-container-title:Cancer Chemother Pharmacol

Author:

Owonikoko Taofeek Kunle,Hussain Arif,Stadler Walter Michael,Smith David C.,Kluger Harriet,Molina Ana M.,Gulati Parul,Shah Aadhar,Ahlers Christoph Matthias,Cardarelli Pina M.,Cohen Lewis J.

Funder

Bristol-Myers Squibb

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Link

http://link.springer.com/content/pdf/10.1007/s00280-015-2909-2.pdf

Reference26 articles.

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3. McEarchern JA, Oflazoglu E, Francisco L, McDonagh CF, Gordon KA, Stone I, Klussman K, Turcott E, van Rooijen N, Carter P, Grewal IS, Wahl AF, Law CL (2007) Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities. Blood 109(3):1185–1192. doi: 10.1182/blood-2006-07-034017

4. Thevanayagam L, Bell A, Chakraborty I, Sufi B, Gangwar S, Zang A, Rangan V, Rao C, Wang Z, Pan C, Chong C, Cardarelli P, Deshpande S, Srinivasan M (2013) Novel detection of DNA-alkylated adducts of antibody-drug conjugates with potentially unique preclinical and biomarker applications. Bioanalysis 5(9):1073–1081. doi: 10.4155/bio.13.57

5. Bowman MR, Crimmins MA, Yetz-Aldape J, Kriz R, Kelleher K, Herrmann S (1994) The cloning of CD70 and its identification as the ligand for CD27. J Immunol 152(4):1756–1761

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