Phase I study of cisdiamminedichloroplatinum in combination with azidothymidine in the treatment of patients with advanced malignancies

Author:

Morgan Robert J.,Newman Edward M.,Sowers Lawrence,Scanlon Kevin,Harrison Jonathan,Akman Steven,Leong Lucille,Margolin Kim,Niland Joyce,Raschko James,Somlo George,Carroll Mary,Chow Warren,Tetef Merry,Hamasaki Victor,Yen Yun,Doroshow James H.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference16 articles.

1. Beitz JG, Damowski JW, Cummings FJ, Browne MJ, Clark JW, Bigley JW, Weitberg AB (1995) Phase I trial of high-dose infused zidovudine combined with leucovorin plus fluorouracil. Cancer Invest 13:464–469

2. Browne MJ, Beitz J, Clark JW, Cummings FJ, Weitberg A, Murray C, Darnowski JW (1993) A phase I study of zidovudine (AZT) combined with methotrexate in patients with advanced cancer (meeting abstract). Proc ASCO 12:A451

3. Brunetti I, Darnowski JW, Falcone A, Johnson KA, Calabresi P (1989) Azidothymidine enhances fluorouracil and methotrexate antitumor and therapeutic activity. Proc Am Assoc Cancer Res 30:A2369

4. Brunetti I, Falcone A, Calabresi P, Goulette FA, Darnowski JW (1990) 5-Fluorouracil enhances azidothymidine cytotoxicity: in vitro, in vivo, and biochemical studies. Cancer Res 50:4026–4031

5. Clark J, Sikov W, Cummings F, Browne M, Akerley W, Wanebo H Weitberg A, Kennedy T, Cole B, Bigley J, Beitz J, Darnowski J (1996) Phase II study of 5-fluorouracil leucovorin and azidothymidine in patients with metastatic colorectal cancer. J Cancer Res Clin Oncol 122:554–558

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