Pharmacokinetics of tablet and liquid formulations of oral 6-mercaptopurine in children with acute lymphoblastic leukemia

Author:

Larsen Rikke Hebo,Hjalgrim Lisa Lyngsie,Grell Kathrine,Kristensen Kim,Pedersen Line Gerner,Brünner Emilie Damgaard,Als-Nielsen Bodil,Schmiegelow KjeldORCID,Nersting JacobORCID

Funder

Kræftens Bekæmpelse

Børnecancerfonden

Barncancerfonden

Nordic Cancer Union

Ingeniør Otto Christensens Fond

Region Hovedstaden

The University Hospital Rigshospitalet

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference28 articles.

1. Toft N, Birgens H, Abrahamsson J, Griskevicius L, Hallbook H, Heyman M, Klausen TW, Jonsson OG, Palk K, Pruunsild K, Quist-Paulsen P, Vaitkeviciene G, Vettenranta K, Asberg A, Frandsen TL, Marquart HV, Madsen HO, Noren-Nystrom U, Schmiegelow K (2018) Results of NOPHO ALL2008 treatment for patients aged 1–45 years with acute lymphoblastic leukemia. Leukemia 32(3):606–615. https://doi.org/10.1038/leu.2017.265

2. Hunger SP, Mullighan CG (2015) Acute lymphoblastic leukemia in children. N Engl J Med 373(16):1541–1552. https://doi.org/10.1056/NEJMra1400972

3. Pieters R, de Groot-Kruseman H, Van der Velden V, Fiocco M, van den Berg H, de Bont E, Egeler RM, Hoogerbrugge P, Kaspers G, Van der Schoot E, De Haas V, Van Dongen J (2016) Successful therapy reduction and intensification for childhood acute lymphoblastic leukemia based on minimal residual disease monitoring: study ALL10 from the Dutch Childhood Oncology Group. J Clin Oncol 34(22):2591–2601. https://doi.org/10.1200/jco.2015.64.6364

4. Dores GM, Devesa SS, Curtis RE, Linet MS, Morton LM (2012) Acute leukemia incidence and patient survival among children and adults in the United States, 2001–2007. Blood 119(1):34–43. https://doi.org/10.1182/blood-2011-04-347872

5. Schmiegelow K, Nielsen SN, Frandsen TL, Nersting J (2014) Mercaptopurine/Methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction. J Pediatr Hematol Oncol 36(7):503–517. https://doi.org/10.1097/mph.0000000000000206

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