Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism

Author:

de Jonge Milly E.,Huitema Alwin D. R.,Holtkamp Marjo J.,van Dam Selma M.,Beijnen Jos H.,Rodenhuis Sjoerd

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference32 articles.

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2. Chang TKH, Weber GF, Crespi CL, Waxman DJ (1993) Differential activation of cyclophosphamide and ifosfamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Res 53:5629–5637

3. Craig AW, Jackson H (1995) The metabolism of 32P-labelled triethylenephosphoramide in relation to its anti-tumour activity. Br J Pharmacol 10:321–325

4. Dando TM, Perry CM (2004) Aprepitant. A review of its use in the prevention of chemotherapy-induced nausea and vomiting. Drugs 64:777–794

5. De Jonge ME, Huitema ADR, Rodenhuis S, Beijnen JH (2004) Integrated population pharmacokinetic model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction. J Pharmacokin Pharmacodyn 31:135–156

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