Population pharmacokinetics of clofarabine and its metabolite 6-ketoclofarabine in adult and pediatric patients with cancer

Author:

Bonate Peter L.,Cunningham Casey C.,Gaynon Paul,Jeha Sima,Kadota Richard,Lam Gilbert N.,Razzouk Bassem,Rytting Michael,Steinherz Peter,Weitman Steve

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference32 articles.

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3. Parker WB, Shaddix SC, Chang CH et al (1991) Effects of 2-chloro-9-(2-deoxy-2-fluoro-betaD-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5¢-triphosphate. Cancer Res 51:2386–2394

4. Genini D, Adachi S, Chao Q et al (2000) Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood 96:3537–3543

5. Xie C, Plunkett W (1995) Metabolism and actions of 2-chloro-9-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl)-adenine in human lymphoblastoid cells. Cancer Res 55:2847–2852

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