Associations among plasma concentrations of regorafenib and its metabolites, adverse events, and ABCG2 polymorphisms in patients with metastatic colorectal cancers

Author:

Kobayashi KazuoORCID,Sugiyama Erika,Shinozaki Eiji,Wakatsuki Takeru,Tajima Masataka,Kidokoro Hiyori,Aoyama TakeshiORCID,Nakano Yasuhiro,Kawakami KazuyoshiORCID,Hashimoto Koki,Suenaga Mitsukuni,Ichimura Takashi,Ogura Mariko,Chin Keisho,Nakayama Izuma,Ooki Akira,Takahari Daisuke,Suzuki Wataru,Yokokawa TakashiORCID,Minowa Yuichi,Hiraoka Tomoko,Suzuki Kenichi,Sato Hitoshi,Hama Toshihiro,Yamaguchi Kensei

Funder

Japan Research Foundation for Clinical Pharmacology

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference30 articles.

1. Wilhelm SM, Dumas J, Adnane L, Lynch M, Carter CA, Schütz G, Thierauch KH, Zopf D (2011) Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer 129(1):245–255. https://doi.org/10.1002/ijc.25864

2. Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, Humblet Y, Bouché O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Sargent DJ, Cihon F, Cupit L, Wagner A, Laurent D, Group CS (2013) Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 381(9863):303–312. https://doi.org/10.1016/S0140-6736(12)61900-X

3. Yoshino T, Komatsu Y, Yamada Y, Yamazaki K, Tsuji A, Ura T, Grothey A, Van Cutsem E, Wagner A, Cihon F, Hamada Y, Ohtsu A (2015) Randomized phase III trial of regorafenib in metastatic colorectal cancer: analysis of the CORRECT Japanese and non-Japanese subpopulations. Investig New Drugs 33(3):740–750. https://doi.org/10.1007/s10637-014-0154-x

4. Yamaguchi K, Komatsu Y, Satoh T, Uetake H, Yoshino T, Nishida T, Yamazaki N, Takikawa H, Morimoto T, Chosa M, Sunaya T, Hamada Y, Muro K, Sugihara K (2019) Large-scale, prospective observational study of regorafenib in Japanese patients with metastatic colorectal cancer in a real-world clinical setting. Oncologist 24(7):e450–e457. https://doi.org/10.1634/theoncologist.2018-0377

5. Van Cutsem E, Martinelli E, Cascinu S, Sobrero A, Banzi M, Seitz JF, Barone C, Ychou M, Peeters M, Brenner B, Hofheinz RD, Maiello E, André T, Spallanzani A, Garcia-Carbonero R, Arriaga YE, Verma U, Grothey A, Kappeler C, Miriyala A, Kalmus J, Falcone A, Zaniboni A (2019) Regorafenib for patients with metastatic colorectal cancer who progressed after standard therapy: results of the large, single-arm, Open-Label Phase IIIb CONSIGN Study. Oncologist 24(2):185–192. https://doi.org/10.1634/theoncologist.2018-0072

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