Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells

Author:

Nathwani Seema-Maria,Butler Stephen,Fayne Darren,McGovern Naomi N.,Sarkadi Balazs,Meegan Mary J.,Lloyd David G.,Campiani Giuseppe,Lawler Mark,Williams D. Clive,Zisterer Daniela M.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference39 articles.

1. Mulligan J, Greene LM, Cloonan S et al (2006) Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1, 5-benzoxazepines. Mol Pharmacol 70:60–70

2. Zisterer DM, Campiani G, Nacci V et al (2000) Pyrrolo-1, 5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents. J Pharmacol Exp Ther 293:48–59

3. Mc Gee MM, Campiani G, Ramunno A et al (2001) Pyrrolo-1, 5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl. J Pharmacol Exp Ther 296:31–40

4. Mc Gee MM, Hyland E, Campiani G et al (2002) Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1, 5-benzoxazepine, PBOX-6. FEBS Lett 515:66–70

5. Mc Gee MM, Campiani G, Ramunno A et al (2002) Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells. J Biol Chem 277:18383–18389

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3