Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of 14C-plitidepsin-Reference-Cited by-同舟云学术

Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of 14C-plitidepsin

Published:2018-07-04 Issue:3 Volume:82 Page:441-455
ISSN:0344-5704
Container-title:Cancer Chemotherapy and Pharmacology
language:en
Short-container-title:Cancer Chemother Pharmacol

Author:

van Andel L.^ORCID,Rosing H.,Tibben M. M.,Lucas L.,Lubomirov R.,Avilés P.,Francesch A.,Fudio S.,Gebretensae A.,Hillebrand M. J. X.,Schellens J. H. M.,Beijnen J. H.

Funder

Pharma Mar, S.A.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Link

http://link.springer.com/article/10.1007/s00280-018-3637-1/fulltext.html

Reference24 articles.

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2. Oliveira H, Thevenot J, Garanger E et al (2014) Nano-encapsulation of plitidepsin: in vivo pharmacokinetics, biodistribution, and efficacy in a renal xenograft tumor model. Pharm Res 31:983–991. https://doi.org/10.1007/s11095-013-1220-3

3. Alonso-Alvarez S, Pardal E, Sanchez-Nieto D et al (2017) Plitidepsin: design, development, and potential place in therapy. Drug Des Devel Ther 11:253–264. https://doi.org/10.2147/DDDT.S94165

4. Losada A, Muñoz-Alonso MJ, García C et al (2016) Translation elongation factor eEF1A2 is a novel anticancer target for the marine natural product plitidepsin. Sci Rep 6:1–15. https://doi.org/10.1038/srep35100

5. Mateos MV, Cibeira MT, Richardson PG et al (2010) Phase II clinical and pharmacokinetic study of plitidepsin 3-h infusion every two weeks alone or with dexamethasone in relapsed and refractory multiple myeloma. Clin Cancer Res 16:3260–3269. https://doi.org/10.1158/1078-0432.CCR-10-0469

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