Population pharmacokinetic analysis of ten phase II clinical trials of pemetrexed in cancer patients

Author:

Latz Jane E,Chaudhary Ajai,Ghosh Atalanta,Johnson Robert D

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference46 articles.

1. Adjei AA (2003) Pemetrexed (Alimta): a novel multitargeted antifolate agent. Expert Rev Anticancer Ther 3:145–156

2. Allen RH, Stabler SP, Savage DG, Lindenbaum J (1993) Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J 7:1344–1353

3. Bajetta E, Celio L, Buzzoni R et al (2003) Phase II study of pemetrexed disodium (Alimta) administered with oral folic acid in patients with advanced gastric cancer. Ann Oncol 14:1543–1548

4. Beal SL, Sheiner LB (1992) NONMEM users guide. NONMEM project group, University of California, San Francisco

5. Bunn P, Paoletti P, Niyikiza C et al (2001) Vitamin B12 and folate reduce toxicity of ALIMTA (pemetrexed disodium, LY231514, MTA), a novel antifolate/antimetabolite. Proc Am Soc Clin Oncol 20:76a

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