Pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (AS1404), a novel vascular disrupting agent, in phase I clinical trial

Author:

Jameson M. B.,Baguley B. C.,Kestell P.,Zhao L.,Paxton J. W.,Thompson P. I.,Waller S.,

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference30 articles.

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2. Baguley BC, Ching LM (1997) Immunomodulatory actions of xanthenone anticancer agents. BioDrugs 8:119–127

3. Baguley B, Jameson M, Zhao L, Dunlop I, Kestell P (1998) Implications of the albumin binding properties of the anticancer drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA) to its clinical trial. Proc Aust Soc Clin Exp Pharmacol Toxicol 5:208a

4. Chabot GG, Bissery MC, Corbett TC, Rutkowski K, Baker LH (1989) Pharmacodynamics and causes of dose-dependent pharmacokinetics of flavone-8-acetic acid (LM-975; NSC-347512) in mice. Cancer Chemother Pharmacol 24:15–22

5. Ching LM, Joseph WR, Crosier KE, Baguley BC (1994) Induction of tumor necrosis factor-alpha messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488). Cancer Res 54:870–872

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