The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI): Incidence and First-Episode Case–Control Programme
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Published:2020-01-23
Issue:5
Volume:55
Page:645-657
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ISSN:0933-7954
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Container-title:Social Psychiatry and Psychiatric Epidemiology
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language:en
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Short-container-title:Soc Psychiatry Psychiatr Epidemiol
Author:
Gayer-Anderson CharlotteORCID, , Jongsma Hannah E., Di Forti Marta, Quattrone Diego, Velthorst Eva, de Haan Lieuwe, Selten Jean-Paul, Szöke Andrei, Llorca Pierre-Michel, Tortelli Andrea, Arango Celso, Bobes Julio, Bernardo Miguel, Sanjuán Julio, Santos José Luis, Arrojo Manuel, Parellada Mara, Tarricone Ilaria, Berardi Domenico, Ruggeri Mirella, Lasalvia Antonio, Ferraro Laura, La Cascia Caterina, La Barbera Daniele, Menezes Paulo Rossi, Del-Ben Cristina Marta, Rutten Bart P., van Os Jim, Jones Peter B., Murray Robin M., Kirkbride James B., Morgan Craig
Abstract
Abstract
Purpose
The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders.
Methods
Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case–control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort.
Conclusions
This resource constitutes the largest and most extensive incidence and case–control study of psychosis ever conducted.
Funder
FP7 Ideas: European Research Council São Paulo Research Foundation
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Social Psychology,Health(social science),Epidemiology
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