Author:
Sideli Lucia,Aas Monica,Quattrone Diego,La Barbera Daniele,La Cascia Caterina,Ferraro Laura,Alameda Luis,Velthorst Eva,Trotta Giulia,Tripoli Giada,Schimmenti Adriano,Fontana Andrea,Gayer-Anderson Charlotte,Stilo Simona,Seminerio Fabio,Sartorio Crocettarachele,Marrazzo Giovanna,Lasalvia Antonio,Tosato Sarah,Tarricone Ilaria,Berardi Domenico,D’Andrea Giuseppe,Amoretti Silvia,Andreu-Bernabeu Álvaro,Baudin Grégoire,Beards Stephanie,Bonetto Chiara,Bonora Elena,Cabrera Bibiana,Carracedo Angel,Charpeaud Thomas,Costas Javier,Cristofalo Doriana,Cuadrado Pedro,Durán-Cutilla Manuel,Ferchiou Aziz,Fraguas David,Franke Nathalie,Frijda Flora,Garcia-Portilla Paz,González Peñas Javier,Hubbard Kathryn,Jamain Stéphane,Jiménez-López Estela,Leboyer Marion,Llorente Cloe,López Montoya Gonzalo,Lorente-Rovira Esther,M. Díaz-Caneja Covadonga,Marcelino Loureiro Camila,Matteis Mario,Messchaart Elles,Moltó Ma Dolores,Mezquida Gisela,Moreno Carmen,Muratori Roberto,Nacher Juan,Parellada Mara,Rapado-Castro Marta,Ruggeri Mirella,Richard Jean-Romain,Rodríguez Solano José Juan,Sáiz Pilar A.,Sánchez-Gutierrez Teresa,Sánchez Emilio,Schürhoff Franck,Seri Marco,Shuhama Rosana,Termorshuizen Fabian,Tronche Anne-Marie,van Dam Daniella,van der Ven Elsje,Arango Celso,Arrojo Manuel,Bernardo Miguel,Bobes Julio,Sanjuán Julio,Santos Jose Luis,Menezes Paulo Rossi,Del-Ben Cristina Marta,Jongsma Hannah E.,Jones Peter B.,Kirkbride James B.,Llorca Pierre-Michel,Tortelli Andrea,Pignon Baptiste,de Haan Lieuwe,Selten Jean-Paul,Van Os Jim,Rutten Bart P.,Bentall Richard,Di Forti Marta,Murray Robin M.,Morgan Craig,Fisher Helen L.,
Abstract
AbstractThis study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Social Psychology,Health (social science),Epidemiology