Irreversible binding to proteins after single and repeated daily oral administration of 4-(2,2-diphenylethyl) imidazole (SC-46264) to the Cynomolgus monkey

Author:

Jacqmin P.,Hérin M.,Cavalier R.,Lesne M.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference7 articles.

1. Calderon P., Cordi A.A., Gillet C.L., et al. (1988): α2-blocking derivatives of imidazole. United States Patent, 4, 738, 979.

2. Hérin M., Delatour C., Jacqmin P., Lesne M. (1993): Determination of SC-46264, an α2-receptor antagonist, in rat and monkey plasma by positive ion chemical ionization GCMS. In preparation.

3. Brodhfuehrer J.I., Chapman D.E., Wilke T.J., Powis G. (1990): Comparative studies of the in vitro metabolism and covalent binding of [14C]-benzene by liver slices and microsomal fraction of mouse, rat, and human. Drug Metab. Dispos., 18, 20–27.

4. Kubow S., Wells P.G. (1989): In vitro bioactivation of phenytoin to a reactive free radical intermediate by prostaglandin synthetase, horseradish peroxidase, and thyroid peroxidase. Mol. Pharmacol., 35, 504–511.

5. Roy D., Snodgrass W.R. (1988): Phenytoin metabolic activation: role of cytochrome P-450, glutathione, age, and sex in rats and mice. Res. Commun. Chem. Pathol. Pharmacol., 59, 173–190.

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