Characterization of N-benzylcarbazole and its metabolites from microsomal mixtures by tandem mass spectrometry

Author:

Ulgen M.,Kajbaf M.,Lamb J. H.,Jahanshahi M.,Gorrod J. W.,Naylor S.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference15 articles.

1. Gorrod J.W., Temple D.J. (1976): The formation of N-hydroxymethyl intermediates in the N-demethylation of N-methylcarbazole in vivo and in vitro. Xenobiotica, 6, 265–274.

2. Koop D.R., Hollenberg P.F. (1980): Liver microsonal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences. Mol. Pharmacol., 17, 118–127.

3. Novak R.F., Koop D.R., Hollenber P.F. (1980): Liver microsomal metabolism of N-methylcarbazole: structural identification of the four major metabolites of N-methylcarbazole using1H Fourier Transform NMR Spectroscopy. Mol. Pharmacol., 17, 128–136.

4. Vatsis K.P., Gurka D.P., Hollenberg P.F. (1980): Involvement of cytochrome b5 in the NADPH-dependent regioselective hydroxylation of N-methylcarbazole by cytochromes P-450 LM2 and P-450 LM4 in a reconstituted liver microsomal enzyme system. In: International Symposium on Biochemistry, Biophysics and Regulation of Cytochrome P-450, Stockholm.

5. Gorrod J.W., Gooderham N.J. (1985): Microsomal N- and C-oxidation of 4-substituted N-benzylanilines. Xenobiotica, 15, 1021–1031.

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