Recombinant Opisthorchis viverrini tetraspanin expressed in Pichia pastoris as a potential vaccine candidate for opisthorchiasis

Author:

Phung Luyen Thi,Chaiyadet Sujittra,Hongsrichan Nuttanan,Sotillo Javier,Dieu Hang Dinh Thi,Tran Canh Quang,Brindley Paul J,Loukas Alex,Laha ThewarachORCID

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Insect Science,General Veterinary,General Medicine,Parasitology

Reference35 articles.

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2. Chaiyadet S, Sotillo J, Smout M, Cantacessi C, Jones MK, Johnson MS, Turnbull L, Whitchurch CB, Potriquet J, Laohaviroj M, Mulvenna J, Brindley PJ, Bethony JM, Laha T, Sripa B, Loukas A (2015) Carcinogenic liver fluke secretes extracellular vesicles that promote cholangiocytes to adopt a tumorigenic phenotype. J Infect Dis 212(10):1636–1645. https://doi.org/10.1093/infdis/jiv291

3. Chaiyadet S, Krueajampa W, Hipkaeo W, Plosan Y, Piratae S, Sotillo J, Smout M, Sripa B, Brindley PJ, Loukas A, Laha T (2017a) Suppression of mRNAs encoding CD63 family tetraspanins from the carcinogenic liver fluke Opisthorchis viverrini results in distinct tegument phenotypes. Sci Rep 7(1):14342. https://doi.org/10.1038/s41598-017-13527-5

4. Chaiyadet S, Smout M, Laha T, Sripa B, Loukas A, Sotillo J (2017b) Proteomic characterization of the internalization of Opisthorchis viverrini excretory/secretory products in human cells. Parasitol Int 66(4):494–502. https://doi.org/10.1016/j.parint.2016.02.001

5. Chaiyadet S, Sotillo J, Krueajampa W, Thongsen S, Brindley PJ, Sripa B, Loukas A, Laha T (2019) Vaccination of hamsters with Opisthorchis viverrini extracellular vesicles and vesicle-derived recombinant tetraspanins induces antibodies that block vesicle uptake by cholangiocytes and reduce parasite burden after challenge infection. PLoS Negl Trop Dis 13(5):e0007450. https://doi.org/10.1371/journal.pntd.0007450

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