Evaluation of the protective efficacy of a Leishmania protein associated with distinct adjuvants against visceral leishmaniasis and in vitro immunogenicity in human cells

Author:

Ribeiro Patrícia A. F.,Dias Daniel S.,Lage Daniela P.,Mendonça Débora V. C.,Vale Danniele L.,Ramos Fernanda F.,Carvalho Lívia M.,Carvalho Ana Maria R. S.,Steiner Bethina T.,Roque Marjorie C.,Oliveira-da-Silva João A.,Oliveira Jamil S.,Tavares Grasiele S. V.,Martins Vívian T.,Chávez-Fumagalli Miguel A.,Roatt Bruno M.,Moreira Ricardo L. F.,Menezes-Souza Daniel,Duarte Mariana C.,Oliveira Mônica C.,Machado-de-Ávila Ricardo A.,Teixeira Antônio L.,Coelho Eduardo A. F.ORCID

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Insect Science,General Veterinary,General Medicine,Parasitology

Reference78 articles.

1. Abbehusen MMC, Cunha J, Suarez MS, Teixeira C, Almeida VDA, Pereira LDS, Bordoni M, Gil-Santana L, Solcà MDS, Fraga DBM, Fischer L, Bozza PT, Veras PST, Valenzuela JG, Kamhawi S, Andrade BB, Brodskyn CI (2018) Immunization of experimental dogs with salivary proteins from Lutzomyia longipalpis, using dna and recombinant canarypox virus induces immune responses consistent with protection against Leishmania infantum. Front Immunol 9:2558

2. Abeijon C, Daifalla N, Krautz-Peterson G, Pizzirani S, Beamer G, Frazatti-Gallina NM, Raw I, Campos-Neto A (2016) Immunogenicity in dogs and protection against visceral leishmaniasis induced by a 14 kDa Leishmania infantum recombinant polypeptide. Trials Vaccinol 5:1–7

3. Adem E, Tajebe F, Getahun M, Kiflie A, Diro E, Hailu A, Shkedy Z, Mengesha B, Mulaw T, Atnafu S, Deressa T, Mathewos B, Abate E, Modolell M, Munder M, Müller I, Takele Y, Kropf P (2016) Successful treatment of human visceral leishmaniasis restores antigen specific IFN-γ, but not IL-10 production. PLoS Negl Trop Dis 10:e0004468

4. Agallou M, Athanasiou E, Samiotaki M, Panayotou G, Karagouni E (2016) Identification of immunoreactive Leishmania infantum protein antigens to asymptomatic dog sera through combined immunoproteomics and bioinformatics analysis. PLoS One 11:e0149894

5. Agallou M, Pantazi E, Tsiftsaki E, Toubanaki DK, Gaitanaki C, Smirlis D, Karagouni E (2018) Induction of protective cellular immune responses against experimental visceral leishmaniasis mediated by dendritic cells pulsed with the N-terminal domain of Leishmania infantum elongation factor-2 and CpG oligodeoxynucleotides. Mol Immunol 103:7–20

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