Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933

Author:

Alaoui Jamali M. Abdellah,Yin Ming-biao,Mazzoni Alessandra,Bankusli Issam,Rustum Youcef M.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference41 articles.

1. Bachur NR (1982) Mechanism of action of doxorubicin. In: Hansen HH (ed) Anthracyclines and cancer chemotherapy. Proceedings of a symposium, Ronneby Brunn, Sweden, October 6?7, p 2

2. Bachur NR, Gordon SL, Gee MV (1977) Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation. Mol Pharmacol 13: 901

3. Bankusli I, Yin M-B, Rustum YM (1987) The use of ?Ca+2 channel blocker? (N-(3,4-dimethoxyphenethyl)-N-methyl-2-(naphthyl)-m-dithione-2-propylamine hydrochloride (DMDP) to overcome multidrug resistance of P-388 cell line. 15th International Congress on Chemotherapy, Istanbul, Turkey, contribution D-30

4. Behrens BC, Louie KG, Hamilton TC, Curt G, Kinsella T, Young RC, Ozols RF (1984) Resistance and cross resistance of human ovarian cancer cell lines to Adriamycin, melphalan and irradiation. Proc Am Assoc Cancer Res 25: 336

5. Berlin V, Hazeltine WA (1981) Reduction of Adriamycin to a semiquinone-free radical by NADPH cytochrome P-450 reductase produces DNA cleavage in a reaction mediated by molecular oxygen. J Biol Chem 256: 4747

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