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Association of SGLT2is with cardiovascular and reproductive diseases: a meta-analysis based on 14 large-scale randomized trials

  • Published:2023-11-29 Issue: Volume: Page:
  • ISSN:1559-0100
  • Container-title:Endocrine
  • language:en
  • Short-container-title:Endocrine

Author:

Li Lei,Dong Yun-Hua,Bai Yun,Tang Zou-Ying,Deng Yu-Mei,Wu Ze,Li Wei-YuanORCID

Funder

Social development projects of Yunnan Province

Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Reference34 articles.

1. T.A. Zelniker, S.D. Wiviott, I. Raz, K. Im, E.L. Goodrich, M.P. Bonaca et al. SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials. Lancet 393(10166), 31–39 (2019). https://doi.org/10.1016/S0140-6736(18)32590-X

2. B.L. Neuen, T. Young, H. Heerspink, B. Neal, V. Perkovic, L. Billot et al. SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endo. 7(11), 845–854 (2019). https://doi.org/10.1016/S2213-8587(19)30256-6

3. F. Zannad, J.P. Ferreira, S.J. Pocock, S.D. Anker, J. Butler, G. Filippatos et al. SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: a meta-analysis of the emperor-reduced and dapa-hf trials. Lancet 396(10254), 819–829 (2020). https://doi.org/10.1016/S0140-6736(20)31824-9

4. M. Vaduganathan, K.F. Docherty, B.L. Claggett, P.S. Jhund, R.A. de Boer, A.F. Hernandez et al. SGLT-2 inhibitors in patients with heart failure: a comprehensive meta-analysis of five randomised controlled trials. Lancet 400(10354), 757–767 (2022). https://doi.org/10.1016/S0140-6736(22)01429-5

5. Nuffield Department of Population Health Renal Studies Group; SGLT2 inhibitor Meta-Analysis Cardio-Renal Trialists' Consortium. Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials. Lancet 400(10365), 1788–1801 (2022). https://doi.org/10.1016/S0140-6736(22)02074-8

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