Safety of gender affirming treatment in assigned female at birth transgender people and association of androgen and estrogen β receptor polymorphisms with clinical outcomes

Author:

Pallotti FrancescoORCID,Senofonte GiuliaORCID,Conflitti Anna ChiaraORCID,Giancotti AntonellaORCID,Anzuini Antonella,Delli Paoli EnricoORCID,Di Chiano SilviaORCID,Faja FabianaORCID,Gatta ValentinaORCID,Mondo AlessandroORCID,Mosconi Maddalena,Rizzo FlavioORCID,Spiniello LorenzoORCID,Lombardo FrancescoORCID,Paoli DonatellaORCID

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Reference52 articles.

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2. W.C. Hembree, P.T. Cohen-Kettenis, L. Gooren, S.E. Hannema, W.J. Meyer, M.H. Murad, S.M. Rosenthal, J.D. Safer, V. Tangpricha, G.G. T’Sjoen, Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 102, 3869–3903 (2017). https://doi.org/10.1210/jc.2017-01658

3. F. Pallotti, G. Senofonte, F, Konstantinidou, S. Di Chiano, F. Faja, F. Rizzo, F. Cargnelutti, C. Krausz, D. Paoli, A. Lenzi et al. Epigenetic Effects of Gender-Affirming Hormone Treatment: A Pilot Study of the ESR2 Promoter’s Methylation in AFAB People. Biomedicines 10 (2022) https://doi.org/10.3390/biomedicines10020459

4. M. Zitzmann, Mechanisms of disease: pharmacogenetics of testosterone therapy in hypogonadal men. Nat. Clin. Pract. Urol. 4, 161–166 (2007). https://doi.org/10.1038/ncpuro0706

5. L. Westberg, F. Baghaei, R. Rosmond, M. Hellstrand, M. Landén, M. Jansson, G. Holm, P. Björntorp, E. Eriksson, Polymorphisms of the androgen receptor gene and the estrogen receptor beta gene are associated with androgen levels in women. J. Clin. Endocrinol. Metab. 86, 2562–2568 (2001). https://doi.org/10.1210/jcem.86.6.7614

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