Computational saturation mutagenesis to explore the effect of pathogenic mutations on extra-cellular domains of TREM2 associated with Alzheimer’s and Nasu-Hakola disease
Author:
Publisher
Springer Science and Business Media LLC
Subject
Computational Theory and Mathematics,Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Catalysis
Link
https://link.springer.com/content/pdf/10.1007/s00894-023-05770-7.pdf
Reference93 articles.
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3. Allcock RJN, Barrow AD, Forbes S, Beck S, Trowsdale J (2003) The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single lgV domain receptors and includes NKp44. Eur J Immunol 33:567–577. https://doi.org/10.1002/immu.200310033
4. Gratuze M, Leyns CEG, Holtzman DM (2018) New insights into the role of TREM2 in Alzheimer’s disease. Mol Neurodegener 13. https://doi.org/10.1186/s13024-018-0298-9
5. Borroni B, Ferrari F, Galimberti D, Nacmias B, Barone C, Bagnoli S, Fenoglio C, Piaceri I, Archetti S, Bonvicini C, Gennarelli M, Turla M, Scarpini E, Sorbi S, Padovani A (2014) Heterozygous TREM2 mutations in frontotemporal dementia. Neurobiol Aging 35(934):e7-934.e10. https://doi.org/10.1016/j.neurobiolaging.2013.09.017
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