Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane?

Author:

Hescheler J.,Pelzer D.,Trube G.,Trautwein W.

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Clinical Biochemistry,Physiology

Reference20 articles.

1. Cahalan M, Shapiro BI, Almers W (1980) Relationship between inactivation of sodium channels and block by quarternary derivatives of local anesthetics and other compounds. In: Fink BR (ed) Progress in anesthesiology. Vol 2, Molecular mechanisms of anesthesia. Raven Press, New York, pp 17?33

2. Courtney KR (1975) Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA968. J Pharmacol Exp Ther 195:225?236

3. Dörrscheidt-Käfer M (1977) The action of D600 on frog skeletal muscle: facilitation of excitation-contraction coupling. Pflügers Arch 369:259?267

4. Grant AO, Strauss LJ, Wallace AG, Strauss HC (1980) The influence of pH on the electrophysiological effects of lidocaine in guinea pig ventricular myocardium. Circ Res 47:542?550

5. Hescheler J, Pelzer D, Trube G, Trautwein W (1981) Action potentials of isolated ventricular cells following intracellular or extracellular application of D600 and its quarternary derivative. Pflügers Arch (Suppl) 391:R1

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