ERK signaling pathway may induce gemcitabine chemoresistance in pancreatic cancer cell line SW1990 by regulating the expression of mdr-1 and RRM1 gene

Author:

Chen Denglin,Xie Derong,Guo Shuangshuang,Yang Qiong,Jiang Zhimin,Bi Zhuofei,Ma Wen

Publisher

Springer Science and Business Media LLC

Subject

Oncology

Reference19 articles.

1. Nieto J, Grossbard ML, Kozuch P. Metastatic pancreatic cancer 2008: is the glass less empty? Oncologist, 2008, 13: 562–576.

2. Yao J, Feng FY, Lin C, et al. The mechanism of resistance to 2′,2′-difluorodeoxyxytidine (gemcitabine) in a pancreatic cancer cell line. Chin J Oncol (Chinese), 2005, 27: 721–726.

3. Nakahira S, Nakamori S, Tsujie M, et al. Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer. Int J Cancer, 2007, 120: 1355–1363.

4. Lu Z, Kleeff J, Shrikhande S, et al. Expression of the multidrug-resistance 1 (mdr1) gene and prognosis in human pancreatic cancer. Pancreas, 2000, 21: 240–247.

5. Messersmith WA, Hidalgo M, Carducci M, et al. Novel targets in solid tumors: MEK inhibitors. Clin Adv Hematol Oncol, 2006, 4: 831–836.

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