Relationship between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia: a meta-analysis*

Abstract

AbstractObjectiveThe aim of the study was to systematically evaluate the correlation betweenIKZF1polymorphisms and the risk of acute lymphoblastic leukemia.MethodsComputer databases including PubMed, EMBASE, and Web of Science were searched for case-control studies on the association betweenIKZF1polymorphisms and the risk of acute lymphoblastic leukemia. The retrieval period was from the establishment of the database to November 2020. Two researchers independently screened the literature, extracted the data, evaluated the risk of bias in the included studies, and used Stata 14.0 software for meta-analysis.ResultsA total of 48 case-control studies were included, with 10 520 and 44 049 cases in the case and control groups, respectively. The meta-analysis results showed that rs4132061 and rs11978267 ofIKZF1were significantly correlated with the risk of acute lymphoblastic leukemia (ALL).ConclusionCurrent evidence indicates that rs4132061 and rs11978267 ofIKZF1are significantly associated with the risk of B-cell ALL.