Author:
Mohamed Wafaa H.,Ali Marwa F.,Yahia Doha,Hussein Hassan A.
Abstract
AbstractThe study objective was to evaluate the potential reproductive toxicity of sulfoxaflor (SFX) insecticide in male Sprague Dawley rats. To attain these objectives, forty male Sprague Dawley rats of 10–12 weeks old were randomly divided into four equal groups; the 1st group was used as a control group; the other three groups were exposed to 25, 100, and 500 mg/kg body weight SFX by oral gavage for 4 weeks. Relative testicular weight, testosterone, FSH, LH, MDA, and GPx levels, sperm viability, sperm morphology, sperm DNA damage, and histopathological changes in testes, epididymis, and seminal vesical of these rats were investigated after 4 weeks. The results showed that SFX exposure resulted in a significant increase in FSH, LH, MDA, and GPx levels as well as the percentage of dead and abnormal sperms and DNA damage in rat sperms. Histopathological examination of testes established testicular degeneration with coagulative necrosis as well as the proliferation of interstitial connective tissue infiltrated with inflammatory cells with congestion of intertubular blood vessels in epididymis and degeneration of lining epithelium of seminal vesicles.
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Pollution,Environmental Chemistry,General Medicine
Reference48 articles.
1. Airaodion AI, Ngwogu AC, Megwas AU, Ekenjoku JA, Ngwogu KO (2019) Effect of common household insecticides used in Nigeria on rat male reproductive hormones. Int J Res Rep in Gynaecol 2(1):1–8
2. Ali RI, Ibrahim MA (2018) Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin. Egypt J Forensic Sci 8:1–13
3. Arıcan EY, Kayalı DG, Karaca BU, Boran T, Öztürk N, Okyar A, Ercan F, Özhan G (2020) Reproductive effects of subchronic exposure to acetamiprid in male rats. J Scientific Reports 10:1–10
4. Authority E F S, Crivellente F, Hart A, Hernandez-Jerez AF, Bennekou SH, Pedersen R, Terron A, Wolterink G, Mohimont L (2019) Establishment of cumulative assessment groups of pesticides for their effects on the nervous system. EFSA J 17(9):5800–5115
5. Bacci L, Convertini S, Rossaro B (2018) A review of sulfoxaflor, a derivative of biological acting substances as a class of insecticides with a broad range of action against many insect pests. J Entomol Acarol Res 50(3):7836
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献