Affiliation:
1. 0000 0000 9130 6822 grid.25055.37 Department of Biology Memorial University of Newfoundland A1B 3X9 St. John’s NL Canada
2. grid.17089.37 Department of Biological Sciences University of Alberta T6G 2E9 Edmonton AB Canada
Abstract
Abstract
The δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine (ACV) tripeptide is the first dedicated intermediate in the biosynthetic pathway leading to the penicillin and cephalosporin classes of β-lactam natural products in bacteria and fungi. It is synthesized nonribosomally by the ACV synthetase (ACVS) enzyme, which has been purified and partially characterized from many sources. Due to its large size and instability, many details regarding the reaction mechanism of ACVS are still not fully understood. In this review we discuss the chronology and associated methodology that led to the discovery of ACVS, some of the main findings regarding its activities, and some recent/current studies being conducted on the enzyme. In addition, we conclude with perspectives on what can be done to increase our understating of this very important protein in the future.
Funder
Natural Sciences and Engineering Research Council of Canada
Publisher
Oxford University Press (OUP)
Subject
Applied Microbiology and Biotechnology,Biotechnology,Bioengineering
Cited by
13 articles.
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