Affiliation:
1. grid.255649.9 0000000121717754 Department of Chemistry and Nano Science Ewha Womans University 120-750 Seoul Republic of Korea
2. grid.214458.e 0000000086837370 Life Sciences Institute University of Michigan 48109 Ann Arbor MI USA
Abstract
Abstract
FK506, a 23-membered macrolide produced by several Streptomyces species, is an immunosuppressant widely used to prevent the rejection of transplanted organs. In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerative activities. Herein, we introduce the biological activities and mechanisms of action of FK506 and discuss recent progress made in understanding its biosynthetic pathway, improving production, and in the mutasynthesis of diverse analogs. Perspectives highlighting further strain improvement and structural diversification aimed at generating more analogs with improved pharmaceutical properties will be emphasized.
Funder
The National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (MISP)
The Intelligent Synthetic Biology Center of the Global Frontier Project funded by MISP
High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs, Republic of Korea
Advanced Production Technology Development Program
Publisher
Oxford University Press (OUP)
Subject
Applied Microbiology and Biotechnology,Biotechnology,Bioengineering
Cited by
35 articles.
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