Affiliation:
1. grid.266515.3 0000 0001 2106 0692 Department of Molecular Biosciences University of Kansas 1200 Sunnyside Ave 66045 Lawrence KS USA
2. grid.418084.1 0000 0000 9582 2314 Centre Armand-Frappier Santé Biotechnologie Institut National de la Recherche Scientifique (INRS) H7V 1B7 Laval Québec Canada
3. grid.16750.35 0000 0001 2097 5006 Department of Chemistry Princeton University 08544 Princeton NJ USA
Abstract
Abstract
Bacterial secondary metabolites play important roles in promoting survival, though few have been carefully studied in their natural context. Numerous gene clusters code for secondary metabolites in the genomes of members of the Bptm group, made up of three closely related species with distinctly different lifestyles: the opportunistic pathogen Burkholderia pseudomallei, the non-pathogenic saprophyte Burkholderia thailandensis, and the host-adapted pathogen Burkholderia mallei. Several biosynthetic gene clusters are conserved across two or all three species, and this provides an opportunity to understand how the corresponding secondary metabolites contribute to survival in different contexts in nature. In this review, we discuss three secondary metabolites from the Bptm group: bactobolin, malleilactone (and malleicyprol), and the 4-hydroxy-3-methyl-2-alkylquinolines, providing an overview of each of their biosynthetic pathways and insight into their potential ecological roles. Results of studies on these secondary metabolites provide a window into how secondary metabolites contribute to bacterial survival in different environments, from host infections to polymicrobial soil communities.
Funder
National Institutes of Health
Canadian Institutes of Health Research
Publisher
Oxford University Press (OUP)
Subject
Applied Microbiology and Biotechnology,Biotechnology,Bioengineering
Cited by
18 articles.
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